CypD-IN-3

Cat. No.: HY-151487: FAQs
Data Sheet Handling Instructions

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CypD-IN-3 is a potent and subtype-selective cyclophilin D (CypD) inhibitor. CypD-IN-3 has CypD affinity with an IC₅₀ value of 0.01 μM. CypD-IN-3 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes.

For research use only. We do not sell to patients.

CypD-IN-3 Chemical Structure

CAS No. : 2651994-75-9

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•Related Small Molecules:

•Related Proteins:

View All Cyclophilin Isoform Specific Products:

View All Isoforms

Cyclophilin A Cyclophilin B Cyclophilin C Cyclophilin D Cyclophilin G Cyclophilin E

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Cyclophilin D

0.01 μM (IC₅₀)

Cyclophilin A

1.1 μM (IC₅₀)

Cyclophilin B

0.21 μM (IC₅₀)

Cyclophilin E

0.31 μM (IC₅₀)

In Vitro

CypD-IN-3 (B52) has selectivity for inhibiting CypD, CypA, CypB and CypE with IC₅₀ values of 0.01 μM, 1.1 μM, 0.21 μM and 0.31 μM, respectively^[1].
CypD-IN-3 (10 μM) inhibits mitochondrial permeability transition pore opening in isolated mitochondria^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

972.09

Formula

C₅₃H₆₁N₇O₁₁

CAS No.

2651994-75-9

SMILES

NCCOCCNC([C@@H]1CCNC(/C=C/C(N2CCC[C@](C2)(C(N[C@H](C(NCC3=C(CC(N1)=O)C=CC=C3)=O)CC4=CC=C(C=C4)C5=CC=C(C=C5)CC(C(O)=O)C(O)=O)=O)CC6=CC=CC=C6)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Alexander A Peterson, et al. Discovery and molecular basis of subtype-selective cyclophilin inhibitors. Nat Chem Biol. 2022 Sep 26. [Content Brief]

CypD-IN-3 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CypD-IN-32651994-75-9Cyclophilincyclophilin D (CypD)CypACypBCypEoxidative stressischemia-reperfusion injury (IRI)neurodegenerative disordersliver diseasesagingautophagydiabetesInhibitorinhibitorinhibit

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