Cytidine-5'-triphosphate-¹³C₉ dilithium  (Synonyms: Cytidine triphosphate-¹³C₉ dilithium; 5'-CTP-¹³C₉ dilithium)

Cytidine-5'-triphosphate-¹³C₉ (Cytidine triphosphate-¹³C₉ dilithium; 5'-CTP-¹³C₉) dilithium is ¹³C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

503.96

¹³C₉H₁₄Li₂N₃O₁₄P₃

65-47-4

Liquid

Colorless to light yellow

O[13C@H]1[13C@@H](O)[13C@H](N2[13C](N=[13C](N)[13CH]=[13CH]2)=O)O[13C@@H]1[13CH2]OP(OP(OP(O)(O[Li])=O)(O[Li])=O)(O)=O

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Heidy Y Narvaez-Ortiz, et al. A CTP Synthase Undergoing Stage-Specific Spatial Expression Is Essential for the Survival of the Intracellular Parasite Toxoplasma gondii. Front Cell Infect Microbiol. 2018 Mar 22;8:83.  [Content Brief]