1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. TRP Channel
  3. D-erythro-Sphingosine hydrochloride

D-erythro-Sphingosine hydrochloride  (Synonyms: Erythrosphingosine hydrochloride; erythro-C18-Sphingosine hydrochloride; trans-4-Sphingenine hydrochloride)

Cat. No.: HY-W089922 Purity: ≥97.0%
Data Sheet SDS COA Handling Instructions Technical Support

D-erythro-Sphingosine (Erythrosphingosine) hydrochloride is a specific TRPM3 activator. D-erythro-Sphingosine also induces retinoblastoma protein dephosphorylation.

For research use only. We do not sell to patients.

D-erythro-Sphingosine hydrochloride Chemical Structure

D-erythro-Sphingosine hydrochloride Chemical Structure

CAS No. : 2673-72-5

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Based on 4 publication(s) in Google Scholar

Other Forms of D-erythro-Sphingosine hydrochloride:

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Description

D-erythro-Sphingosine (Erythrosphingosine) hydrochloride is a specific TRPM3 activator. D-erythro-Sphingosine also induces retinoblastoma protein dephosphorylation[1][2].

IC50 & Target[1][2]

TRPM3

 

Retinoblastoma protein

 

In Vitro

Extracellular application of D-erythro-Sphingosine (20 μM) induces an increase in [Ca2+]i in TRPM3-transfected HEK293 cells within 20 to 30 s after start of application, whereas nontransfected control cells (NT) shows only very small responses[1].
D-erythro-Sphingosine (10 μM) induces currents through TRPM3[1].
Induction of retinoblastoma protein dephosphorylation by D-erythro-Sphingosine (500 nM; 24 h) precede inhibition of growth and a specific arrest in the G0/G1 phase of the cell cycle[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

335.95

Formula

C18H38ClNO2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO.[H]Cl

Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 50 mg/mL (148.83 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9766 mL 14.8832 mL 29.7663 mL
5 mM 0.5953 mL 2.9766 mL 5.9533 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation

Purity: ≥97.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.9766 mL 14.8832 mL 29.7663 mL 74.4158 mL
5 mM 0.5953 mL 2.9766 mL 5.9533 mL 14.8832 mL
10 mM 0.2977 mL 1.4883 mL 2.9766 mL 7.4416 mL
15 mM 0.1984 mL 0.9922 mL 1.9844 mL 4.9611 mL
20 mM 0.1488 mL 0.7442 mL 1.4883 mL 3.7208 mL
25 mM 0.1191 mL 0.5953 mL 1.1907 mL 2.9766 mL
30 mM 0.0992 mL 0.4961 mL 0.9922 mL 2.4805 mL
40 mM 0.0744 mL 0.3721 mL 0.7442 mL 1.8604 mL
50 mM 0.0595 mL 0.2977 mL 0.5953 mL 1.4883 mL
60 mM 0.0496 mL 0.2481 mL 0.4961 mL 1.2403 mL
80 mM 0.0372 mL 0.1860 mL 0.3721 mL 0.9302 mL
100 mM 0.0298 mL 0.1488 mL 0.2977 mL 0.7442 mL
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D-erythro-Sphingosine hydrochloride
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