[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH 

[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH acts as a GnRH receptor antagonist^[1].

GnRH receptor^[1]

[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH (1 μM), together with LH-RH and FSH, blocks the inhibition of FSH-induced steroidogenesis in rat ovary granulosa cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH (1.25 and 2.5 mg, subcutaneous injection, b.i.d, for 7 days) prolongs pregnancy in rats^[1].
[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH (250 μg) inhibits ovulation by 100% in rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1321.48

C₆₇H₈₄N₁₆O₁₃

68059-94-9

{d-Glp}-{d-Phe}-{d-Trp}-SY-{d-Trp}-LRPG-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Rivier C, et al. Effect of the LRF-antagonist [D-pGlu1, D-Phe2, D-Trp3,6]-LRF on pregnancy in the rat. Contraception. 1979 Feb;19(2):185-90.  [Content Brief]

  [2]. Rivier JE, et al. A potent luteinizing hormone releasing factor antagonist in vitro and inhibitor of ovulation in the rat. Life Sci. 1978 Aug 28;23(8):869-76.  [Content Brief]

  [3]. Hsueh AJ, et al. Effect on an antagonistic analog of gonadotropin releasing hormone upon ovarian granulosa cell function. Life Sci. 1979 Oct 1;25(14):1223-9.  [Content Brief]