D-Mannitol-d₂  (Synonyms: Mannitol-d₂; Mannite-d₂)

D-Mannitol-d₂ is the deuterium labeled D-Mannitol.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

184.18

C₆H₁₂D₂O₆

2649096-16-0

69-65-8

OC([2H])([2H])[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Tan, K., et al., The mannitol operon repressor MtlR belongs to a new class of transcription regulators in bacteria. J Biol Chem, 2009. 284(52): p. 36670-9.;Nishiyama, A., et al., Mannitol lowers fat digestibility and body fat accumulation in both normal a  [Content Brief]