[D-Trp34]-Neuropeptide Y 

[D-Trp34]-Neuropeptide Y is a potent and selective neuropeptide Y (NPY) Y₅ receptor agonist. [D-Trp34]-Neuropeptide Y is a significantly less potent agonist at the NPY Y₁, Y₂, Y₄, and y₆ receptors. [D-Trp34]-Neuropeptide Y markedly increases food intake in rats^[1][2].

[D-Trp34]-Neuropeptide Y has pK_i values of 6.49, 5.43, 7.08, 7.53, 6.55, 5.95, 6.85, 7.41 for hY₁, hY₂, hY₄, hY₅, rY₁, rY₂, rY₄, rY₅ in CHO cells. [D-Trp34]-Neuropeptide Y has pEC₅₀ values of 6.44, <6, 6.28，7.82 for rY₁, rY₂ in CHO cells and rY₄, rY₅ in HEK-293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

[D-Trp34]-Neuropeptide Y (0, 8 and 16 μg/rat; I.C.V) stimulats food intake to the same extent in both lean and obese rats 1 h after injection at a dose of 16 μg in male Zucker rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4311.72

C₁₉₆H₂₈₉N₅₅O₅₆

153549-84-9

Solid

White to off-white

YPSKPDNPGEDAPAEDLARYYSALRHYINLITR-{D-Trp}-RY-NH2

[YPSKPDNPGEDAPAEDLARYYSALRHYINLITR-{D-Trp}-RY-NH2]

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

• [1]. E M Parker, et al. [D-Trp(34)] neuropeptide Y is a potent and selective neuropeptide Y Y(5) receptor agonist with dramatic effects on food intake. Peptides. 2000 Mar;21(3):393-9.  [Content Brief]

  [2]. Bernard Beck, et al. Responsiveness of obese Zucker rats to [D-Trp34]-NPY supports the targeting of Y₅ receptor for obesity treatment. Nutr Neurosci. Oct-Dec 2007;10(5-6):211-4.  [Content Brief]