2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Membrane Transporter/Ion Channel PI3K/Akt/mTOR
  3. Reactive Oxygen Species ATP Synthase mTOR Endogenous Metabolite
  4. D-α-Hydroxyglutaric acid disodium (Standard)

D-α-Hydroxyglutaric acid disodium (Standard)  (Synonyms: Disodium (R)-2-hydroxyglutarate (Standard))

Cat. No.: HY-100542R Purity: ≥98%
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D-α-Hydroxyglutaric acid (disodium) (Standard) is the analytical standard of D-α-Hydroxyglutaric acid (disodium). This product is intended for research and analytical applications. D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling[1][2][3][4][5].

For research use only. We do not sell to patients.

D-α-Hydroxyglutaric acid disodium (Standard) Chemical Structure

D-α-Hydroxyglutaric acid disodium (Standard) Chemical Structure

CAS No. : 103404-90-6

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Description
Molecular Weight

192.08

Formula

C5H6Na2O5
CAS No.
SMILES

O=C(O[Na])[C@H](O)CCC(O[Na])=O
Structure Classification
Initial Source
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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D-α-Hydroxyglutaric acid disodium (Standard) Related Classifications

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Keywords:

D-α-Hydroxyglutaric acid disodium (Standard)103404-90-6Disodium (R)-2-hydroxyglutarate (Standard)Reactive Oxygen SpeciesATP SynthasemTOREndogenous MetaboliteMammalian target of RapamycinCeKDM7Aα-ketoglutarateH3K9me2H3K27me2competitorIDH1IDH25-methlycytosineexcitotoxicneurotoxicInhibitorinhibitorinhibit

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