2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. D3S-001

D3S-001 is an orally active inhibitor for KRAS. D3S-001 inhibits the proliferation of KRASG12C mutant H358 and MIA-PA-CA-2 with an IC50 of 0.6 and 0.44 nM. D3S-001 exhibits good metabolic stability in hepatocytes, liver microsomes, plasma and whole blood in various species. D3S-001 exhibits good pharmacokinetic characteristics and antitumor efficacy in mice.

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D3S-001 Chemical Structure

D3S-001 Chemical Structure

CAS No. : 2914919-85-8

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D3S-001 Related Antibodies

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Description

D3S-001 is an orally active inhibitor for KRAS. D3S-001 inhibits the proliferation of KRASG12C mutant H358 and MIA-PA-CA-2 with an IC50 of 0.6 and 0.44 nM. D3S-001 exhibits good metabolic stability in hepatocytes, liver microsomes, plasma and whole blood in various species. D3S-001 exhibits good pharmacokinetic characteristics and antitumor efficacy in mice[1].

Molecular Weight

679.66

Formula

C32H35F6N7O3
CAS No.
SMILES

FC(F)(F)C(C(C)=CC(N)=C1F)=C1[C@@H]2CC3=NC(OC[C@@]45N(CCC5)C[C@@H](C4)F)=NC(N6C[C@@H](N(CC6)C(C(F)=C)=O)CC#N)=C3CO2
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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D3S-001 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D3S-0012914919-85-8RasMIA-PA-CA-2NCI-H358CD-1 mouseSprague-Dawley ratorally activeInhibitorinhibitorinhibit

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