2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. Daltroban

Daltroban  (Synonyms: BM-13505; SKF 96148)

Cat. No.: HY-121018 Purity: 98.1%
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Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist. Daltroban increase intracellular calcium in vascular smooth muscle cells. Daltroban shows protective effect in reperfusion injury.

For research use only. We do not sell to patients.

Daltroban Chemical Structure

Daltroban Chemical Structure

CAS No. : 79094-20-5

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Based on 1 publication(s) in Google Scholar

Daltroban Related Antibodies

Top Publications Citing Use of Products

View All Prostaglandin Receptor Isoform Specific Products:

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DP EP FP IP TXA2/TP TXB2

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Description

Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist. Daltroban increase intracellular calcium in vascular smooth muscle cells. Daltroban shows protective effect in reperfusion injury[1][2].

IC50 & Target

TXA2

 

In Vivo

Daltroban (BM-13505) (1 mg/kg; i.v.; per hour) exerts protective effect in reperfusion injury following acute myocardial ischemia in cats[2].
In comparison with vehicle (physiological saline)-treated cats, Daltroban (20 mg/kg per hour i.v.) reduces the ischaemia-induced rise in the ST segment and prevented the development of a Q-wave in the ECG during reperfusion. Daltroban protects the myocardium from ischaemic injury and that this effect involves prevention of ischaemia-induced leukocytosis[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male cats (2.8 to 4.6 kg; anesthetized cat model)[2]
Dosage: 1 mg/kg
Administration: i.v.; 30 minutes before reperfusion at a rate of 1 mg/kg followed by 1 mg/kg/hour
Result: Significantly reduced the area of ischemic tissue as a percent of total left ventricular mass and total area at risk, without altering basic hemodynamics and thereby not influencing myocardial oxygen demand.
Molecular Weight

353.82

Formula

C16H16ClNO4S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(CC1=CC=C(C=C1)CCNS(=O)(C2=CC=C(C=C2)Cl)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 22 mg/mL (62.18 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8263 mL 14.1315 mL 28.2630 mL
5 mM 0.5653 mL 2.8263 mL 5.6526 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.1%

COA (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8263 mL 14.1315 mL 28.2630 mL 70.6574 mL
5 mM 0.5653 mL 2.8263 mL 5.6526 mL 14.1315 mL
10 mM 0.2826 mL 1.4131 mL 2.8263 mL 7.0657 mL
15 mM 0.1884 mL 0.9421 mL 1.8842 mL 4.7105 mL
20 mM 0.1413 mL 0.7066 mL 1.4131 mL 3.5329 mL
25 mM 0.1131 mL 0.5653 mL 1.1305 mL 2.8263 mL
30 mM 0.0942 mL 0.4710 mL 0.9421 mL 2.3552 mL
40 mM 0.0707 mL 0.3533 mL 0.7066 mL 1.7664 mL
50 mM 0.0565 mL 0.2826 mL 0.5653 mL 1.4131 mL
60 mM 0.0471 mL 0.2355 mL 0.4710 mL 1.1776 mL
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Daltroban Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Daltroban79094-20-5BM-13505 SKF 96148BM13505BM 13505SKF96148SKF 96148SKF-96148Prostaglandin ReceptorselectiveischaemicinjuryprotectivevascularsmoothmusclecellsInhibitorinhibitorinhibit

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