2. Immunology/Inflammation Antibody-drug Conjugate/ADC Related
  3. CD38 ADC Antibody
  4. Daratumumab

Daratumumab  (Synonyms: Anti-Human CD38, Human Antibody)

Cat. No.: HY-P9915 Purity: 99.00%
COA

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Daratumumab (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition.

For research use only. We do not sell to patients.

CAS No. : 945721-28-8

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5 mg USD 620 In-stock
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Based on 1 publication(s) in Google Scholar

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Daratumumab Related Antibodies

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Description

Daratumumab (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition[1][2].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Human
In Vitro

Daratumumab (Anti-Human CD38) induces potent Ab-dependent cellular cytotoxicity in CD38-expressing lymphoma- and MM-derived cell lines[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Daratumumab Related Antibodies
In Vivo

Daratumumab (i.p.; 0.5 mg/kg; 14 d after challenge with Daudi-luc cells) inhibits outgrowth of CD38-expressing tumor cells in mouse xenograft tumor models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8- to 10-wk-old C.B-17 SCID mice (luciferase-expressing Daudi cells)[2]
Dosage: 0.5 mg/kg
Administration: I.p.; 14 day after challenge with Daudi-luc cells
Result: Effectively inhibited tumor growth compared with control-treated animals in which tumor grew rapidly and therefore required euthanasia on day 35. On day 28 and day 35, tumor size in Daratumumab-treated animals was significantly different from the control.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Daratumumab]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Flow cytometry analysis of Raji cells labelling CD38 with Daratumumab at 100nM (Red). Goat anti human IgG Fc(Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
  • Daratumumab has a significant CDC effect on Raji cells in a dose-dependent manner. The EC50 for this effect is 96.2 and 98.6 ng/mL.
Purity & Documentation

Purity: 99.00%

COA (231 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Daratumumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Daratumumab945721-28-8Anti-Human CD38, Human AntibodyCD38ADC AntibodymyelomacelladhesioncytotoxicitytumorMMNKantibodyInhibitorinhibitorinhibit

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