2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. DAT1

DAT1 is a potent antimitotic agent with anticancer effects. In HeLa cells, DAT1 blocks the spindle function by disturbing spindle microtubule and chromosome organization.

For research use only. We do not sell to patients.

DAT1 Chemical Structure

DAT1 Chemical Structure

CAS No. : 107401-70-7

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DAT1 Related Antibodies

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Description

DAT1 is a potent antimitotic agent with anticancer effects. In HeLa cells, DAT1 blocks the spindle function by disturbing spindle microtubule and chromosome organization[1].

In Vitro

DAT1 shows cytotoxicity with GI50 values ranging from 0.05 to 1 μM in different malignant cell lines (human tumour cells from cervix, colon and lung and mouse fibrosarcoma cells) with an average value of 0.35 μM. DAT1 blocks mitosis in the prometaphase and metaphase stages[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DAT1 Related Antibodies
Molecular Weight

325.38

Formula

C17H15N3O2S
CAS No.
SMILES

O=C(C1=C(N)N=C(NC2=CC=C(C=C2)OC)S1)C3=CC=CC=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DAT1 Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DAT1107401-70-7DAT 1DAT-1Microtubule/Tubulinantimitotic agentanticancer effectsspindle microtubulechromosome organizationInhibitorinhibitorinhibit

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