2. NF-κB Protein Tyrosine Kinase/RTK Immunology/Inflammation GPCR/G Protein
  3. NF-κB Prostaglandin Receptor NO Synthase Syk
  4. DBMB

DBMB is an inhibitor of spleen tyrosine kinase (Syk), capable of significantly inhibiting the activity of Syk kinase. DBMB exhibits anti-inflammatory activity by suppressing the signaling of NF-κB, which in turn reduces the production of inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2). DBMB can be utilized in research on inflammatory diseases.

For research use only. We do not sell to patients.

DBMB Chemical Structure

DBMB Chemical Structure

CAS No. : 314027-66-2

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DBMB Related Antibodies

Top Publications Citing Use of Products

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nNOS iNOS eNOS

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Description

DBMB is an inhibitor of spleen tyrosine kinase (Syk), capable of significantly inhibiting the activity of Syk kinase. DBMB exhibits anti-inflammatory activity by suppressing the signaling of NF-κB, which in turn reduces the production of inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2). DBMB can be utilized in research on inflammatory diseases[1].

Molecular Weight

382.46

Formula

C24H22N4O
CAS No.
SMILES

COC1=C(C=CC=C1)CC(C2=NC3=C(N2)C=CC=C3)CC4=NC5=C(N4)C=CC=C5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DBMB Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DBMB314027-66-2NF-κBProstaglandin ReceptorNO SynthaseSykNuclear factor-κBNuclear factor-kappaBNitric oxide synthasesNOSSpleen tyrosine kinaseinflammatory diseasesInflammationRAW264.7Inhibitorinhibitorinhibit

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