2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. DCG-IV

DCG-IV is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1R/5R=389/630 μM) and III receptors (IC50: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects.

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DCG-IV Chemical Structure

DCG-IV Chemical Structure

CAS No. : 147782-19-2

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Based on 1 publication(s) in Google Scholar

DCG-IV Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

DCG-IV is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1R/5R=389/630 μM) and III receptors (IC50: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects[1][2].

IC50 & Target[1]

mGluR2R

0.35 μM (EC50)

mGluR3R

0.09 μM (EC50)

mGluR1R

389 μM (IC50)

mGluR5

630 μM (IC50)

mGluR4R

22.5 μM (IC50)

mGluR6

39.6 μM (IC50)

mGluR7

40.1 μM (IC50)

mGluR8

32 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
45 nM
Compound: DCG-IV
Agonist activity at rat mGlu2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 1 hr by fluorescence microplate reader
Agonist activity at rat mGlu2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 1 hr by fluorescence microplate reader
[PMID: 20218620]
In Vitro

DCG-IV is also an NMDA receptor agonist in the rat cortical slice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DCG-IV Related Antibodies
In Vivo

DCG-IV (1-10 mg/kg; i.p.) depresses the phencyclidine (PCP)-induced hyperlocomotion[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice weighing about 40 g (PCP-induced locomotor activity)[4]
Dosage: 10, 5, or 1 mg/kg
Administration: I.p.
Result: Reduced spontaneous activities of the animals at 10 or 5 mg/kg.
Molecular Weight

203.15

Formula

C7H9NO6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1[C@H](C(O)=O)C1[C@H](N)C(O)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 20 mg/mL (98.45 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9225 mL 24.6124 mL 49.2247 mL
5 mM 0.9845 mL 4.9225 mL 9.8449 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.9225 mL 24.6124 mL 49.2247 mL 123.0618 mL
5 mM 0.9845 mL 4.9225 mL 9.8449 mL 24.6124 mL
10 mM 0.4922 mL 2.4612 mL 4.9225 mL 12.3062 mL
15 mM 0.3282 mL 1.6408 mL 3.2816 mL 8.2041 mL
20 mM 0.2461 mL 1.2306 mL 2.4612 mL 6.1531 mL
25 mM 0.1969 mL 0.9845 mL 1.9690 mL 4.9225 mL
30 mM 0.1641 mL 0.8204 mL 1.6408 mL 4.1021 mL
40 mM 0.1231 mL 0.6153 mL 1.2306 mL 3.0765 mL
50 mM 0.0984 mL 0.4922 mL 0.9845 mL 2.4612 mL
60 mM 0.0820 mL 0.4102 mL 0.8204 mL 2.0510 mL
80 mM 0.0615 mL 0.3077 mL 0.6153 mL 1.5383 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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DCG-IV Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DCG-IV147782-19-2mGluRMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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