Dde Biotin-PEG4-TAMRA-PEG4 Alkyne 

Dde Biotin-PEG4-TAMRA-PEG4 Alkyne is a dye derivative of TAMRA (HY-135640) modified with a cleavable biotin group. Dde Biotin-PEG4-TAMRA-PEG4 Alkyne contains Alkyne groups that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1412.69

C₇₂H₁₀₁N₉O₁₈S

2353409-55-7

OC(C(C=C(C(NCCC(N(CCOCCOCCOCCOCC#C)CCC(NCCCN/C(CCOCCOCCOCCOCCNC(CCCC[C@H]1[C@](NC2=O)([H])[C@](N2)([H])CS1)=O)=C(C3=O)/C(CC(C)(C)C3)=O)=O)=O)=O)C=C4)=C4C5=C(C=CC(N)=C6)C6OC7=C5C=CC(N(C)C)=C7)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562  [Content Brief]