DDO-2213

Cat. No.: HY-153331: FAQs
Data Sheet Handling Instructions

Molarity Calculator

DDO-2213 is an orally active and potent WDR5-MLL1 inhibitor, with an IC₅₀ of 29 nM and a K_d value of 72.9 nM for the WDR5 protein. DDO-2213 selectively inhibits MLL (mixed lineage leukemia) histone methyltransferase activity and the proliferation of MLL translocation-harboring cells. DDO-2213 can be used for MLL fusion leukemia research.

For research use only. We do not sell to patients.

DDO-2213 Chemical Structure

CAS No. : 2378768-36-4

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HUVEC	IC₅₀	> 100 μM Compound: 63; DDO-2213	Antiproliferative activity against human HUVEC cells assessed as cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human HUVEC cells assessed as cell viability incubated for 72 hrs by CCK8 assay	[PMID: 34105966]
K562	IC₅₀	> 100 μM Compound: 63; DDO-2213	Antiproliferative activity against human K562 cells assessed as cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human K562 cells assessed as cell viability incubated for 72 hrs by CCK8 assay	[PMID: 34105966]
MOLM-13	GI₅₀	13.09 μM Compound: DDO-2213	Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell proliferation measured after 5 days by ATPlite assay Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell proliferation measured after 5 days by ATPlite assay	[PMID: 34283608]
MOLM-13	IC₅₀	13.1 μM Compound: 63; DDO-2213	Antiproliferative activity against human MOLM-13 cells assessed as cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human MOLM-13 cells assessed as cell viability incubated for 72 hrs by CCK8 assay	[PMID: 34105966]
MV4-11	GI₅₀	12.57 μM Compound: DDO-2213	Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation measured after 5 days by ATPlite assay Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation measured after 5 days by ATPlite assay	[PMID: 34283608]
MV4-11	IC₅₀	12.6 μM Compound: 63; DDO-2213	Antiproliferative activity against human MV4-11 cells assessed as cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human MV4-11 cells assessed as cell viability incubated for 72 hrs by CCK8 assay	[PMID: 34105966]

Molecular Weight

483.97

Formula

C₂₄H₂₇ClFN₇O

CAS No.

2378768-36-4

SMILES

O=C(C1=CC=C(C2=CC(NC3=NC=NC(Cl)=C3N)=C(N4CCN(C)CC4)C=C2F)C=C1)N(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chen W, et al. Discovery of DDO-2213 as a Potent and Orally Bioavailable Inhibitor of the WDR5-Mixed Lineage Leukemia 1 Protein-Protein Interaction for the Treatment of MLL Fusion Leukemia. J Med Chem. 2021 Jun 24;64(12):8221-8245. [Content Brief]

DDO-2213 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DDO-22132378768-36-4DDO2213DDO 2213WDR5WD repeat protein-5WD40 repeat domain protein 5MLL Fusion LeukemiaWD repeat-containing protein 5MV4-11 tumorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks