2. Epigenetics Apoptosis
  3. Epigenetic Reader Domain Apoptosis
  4. DDO-8958

DDO-8958 is an orally active and selective BET BD1 inhibitor with a KD of 5.6 nM for BRD4 BD1. DDO-8958 exhibits low nanomolar inhibitory activity against all BET BD1 bromodomains except for BRDT BD1. DDO-8958 can inhibit the proliferation and migration, induce apoptosis and cell cycle arrest of tumor cells. DDO-8958 has anti-tumor activity.

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DDO-8958 Chemical Structure

DDO-8958 Chemical Structure

CAS No. : 3017180-18-3

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Description

DDO-8958 is an orally active and selective BET BD1 inhibitor with a KD of 5.6 nM for BRD4 BD1. DDO-8958 exhibits low nanomolar inhibitory activity against all BET BD1 bromodomains except for BRDT BD1. DDO-8958 can inhibit the proliferation and migration, induce apoptosis and cell cycle arrest of tumor cells. DDO-8958 has anti-tumor activity[1].

Molecular Weight

407.44

Formula

C22H22FN5O2
CAS No.
SMILES

FC1=C(C=C(C=C1C2=C3NC=NC3=NC=C2)OCC4COC4)C5=C(N(N=C5C)C)C
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DDO-8958 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DDO-89583017180-18-3DDO8958DDO 8958Epigenetic Reader DomainApoptosisMIA PaCa-2SW1990PANC-1HPACPancreatic cancer modelInhibitorinhibitorinhibit

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