2. Protein Tyrosine Kinase/RTK
  3. Discoidin Domain Receptor
  4. DDR1-IN-1 dihydrochloride

DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC50 of 105 nM; 4-fold less potent for DDR2 (IC50 = 413 nM).

For research use only. We do not sell to patients.

DDR1-IN-1 dihydrochloride Chemical Structure

DDR1-IN-1 dihydrochloride Chemical Structure

CAS No. : 1780303-76-5

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DDR1-IN-1 dihydrochloride Related Antibodies

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DDR1 DDR2

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Description

DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC50 of 105 nM; 4-fold less potent for DDR2 (IC50 = 413 nM)[1].

IC50 & Target[1]

DDR1

105 nM (IC50)

DDR2

413 nM (IC50)

In Vitro

DDR1-IN-1 effectively blocks collagen-induced DDR1 pY513 autophosphorylation in U2OS cells (EC50 = 86.76 nM) with excellent selectivity over a panel of >380 kinases. DDR1-IN-1 inhibits DDR2-mediated MT1-MMP activation in human rheumatoid synovial fibroblasts (RASF) upon collagen stimulation (IC50 < 2.5 μM) and enhances PI3K/mTOR inhibitor GSK2126458 antiproliferation efficacy in SNU-1040 colorectal cancer culture[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DDR1-IN-1 dihydrochloride Related Antibodies
Molecular Weight

625.51

Formula

C30H33Cl2F3N4O3
CAS No.
SMILES

CC1=C(C=C(C=C1)NC(C2=CC=C(C(C(F)(F)F)=C2)CN3CCN(CC3)CC)=O)OC4=CC(C5)=C(C=C4)NC5=O.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DDR1-IN-1 dihydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DDR1-IN-11780303-76-5Discoidin Domain ReceptorInhibitorinhibitorinhibit

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Product Name:
DDR1-IN-1 dihydrochloride
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HY-13979A
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