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  4. Deacetyldiltiazem

Deacetyldiltiazem is a metabolite with coronary vasodilator activity. Deacetyldiltiazem is present in the plasma of individuals taking Diltiazem. The deacetylase activity of deacetyldiltiazem is mainly catalyzed by the rat Ces2a enzyme. In vitro experiments of deacetyldiltiazem showed that its Km value was similar to that of rat liver microsomes, showing efficient deacetylase activity. The study of deacetyldiltiazem helps to understand the differences in the metabolic kinetics of compounds between different species.

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Deacetyldiltiazem Chemical Structure

Deacetyldiltiazem Chemical Structure

CAS No. : 42399-40-6

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Deacetyldiltiazem Related Antibodies

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Description

Deacetyldiltiazem is a metabolite with coronary vasodilator activity. Deacetyldiltiazem is present in the plasma of individuals taking Diltiazem. The deacetylase activity of deacetyldiltiazem is mainly catalyzed by the rat Ces2a enzyme. In vitro experiments of deacetyldiltiazem showed that its Km value was similar to that of rat liver microsomes, showing efficient deacetylase activity. The study of deacetyldiltiazem helps to understand the differences in the metabolic kinetics of compounds between different species[1].

Molecular Weight

372.48

Formula

C20H24N2O3S
CAS No.
SMILES

CN(C)CCN1C2=CC=CC=C2S[C@@H](C3=CC=C(C=C3)OC)[C@H](C1=O)O
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Deacetyldiltiazem Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Deacetyldiltiazem42399-40-6OthersInhibitorinhibitorinhibit

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