Debromohymenialdisine (Synonyms: 10Z-Debromohymenialdisine)

Cat. No.: HY-113632: FAQs
Data Sheet Handling Instructions Technical Support

Debromohymenialdisine (10Z-Debromohymenialdisine) is a pyrrole alkaloid. Debromohymenialdisine has moderate inhibitory activity with an IC₅₀ value of 881 nM in the initial Raf/MEK-1/MAPK signaling cascade assay. Debromohymenialdisine can be used for the research of proliferation and differentiation.

For research use only. We do not sell to patients.

Debromohymenialdisine Chemical Structure

CAS No. : 75593-17-8

Size		Stock
100 μg		Get quote	Estimated Time of Arrival: December 31

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Raf Isoform Specific Products:

View All Isoforms

BRaf c-Raf Raf

View All MEK Isoform Specific Products:

View All Isoforms

MEK1 MEK2 MEK5 MEK

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: 881 nM (in Raf/MEK-1/MAPK signaling cascade assay)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A498	ED₅₀	24.7 μg/mL Compound: 2	Cytotoxicity against human A498 cells by SRB assay Cytotoxicity against human A498 cells by SRB assay	[PMID: 9051914]
KM-20L2	ED₅₀	8.5 μg/mL Compound: 2	Cytotoxicity against human KM20L2 cells by SRB assay Cytotoxicity against human KM20L2 cells by SRB assay	[PMID: 9051914]
L5178Y	EC₅₀	1.8 μg/mL Compound: 1d; DBH	Cytotoxicity against mouse L5178Y cells by MTT assay Cytotoxicity against mouse L5178Y cells by MTT assay	[PMID: 33901899]
MONO-MAC-6	IC₅₀	2.4 μg/mL Compound: 5	Cytotoxicity against human MONO-MAC 6 cells assessed as [3H]thymidine incorporation after 48 hrs Cytotoxicity against human MONO-MAC 6 cells assessed as [3H]thymidine incorporation after 48 hrs	[PMID: 9917317]
MONO-MAC-6	IC₅₀	9.67 μM Compound: 7	Cytotoxicity against human MONO-MAC-6 cells incubated for 48 hrs by [3H]-thymidine incorporation based liquid scintillation counter analysis Cytotoxicity against human MONO-MAC-6 cells incubated for 48 hrs by [3H]-thymidine incorporation based liquid scintillation counter analysis	[PMID: 36496202]
NCI-H460	ED₅₀	42 μg/mL Compound: 2	Cytotoxicity against human H460 cells by SRB assay Cytotoxicity against human H460 cells by SRB assay	[PMID: 9051914]
OVCAR-3	ED₅₀	1.8 μg/mL Compound: 2	Cytotoxicity against human OVCAR-3 cells by SRB assay Cytotoxicity against human OVCAR-3 cells by SRB assay	[PMID: 9051914]
SF-295	ED₅₀	38.9 μg/mL Compound: 2	Cytotoxicity against human SF295 cells by SRB assay Cytotoxicity against human SF295 cells by SRB assay	[PMID: 9051914]
SK-MEL-5	ED₅₀	5.7 μg/mL Compound: 2	Cytotoxicity against human SK-MEL-5 cells by SRB assay Cytotoxicity against human SK-MEL-5 cells by SRB assay	[PMID: 9051914]

In Vitro

Debromohymenialdisine has moderate inhibitory activity with an IC₅₀ value of 881 nM in the initial Raf/MEK-1/MAPK signaling cascade assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

245.24

Formula

C₁₁H₁₁N₅O₂

CAS No.

75593-17-8

SMILES

NC(N/C1=C2CCNC(C3=C/2C=CN3)=O)=NC1=O

Structure Classification

Others

Initial Source

Stylissa massa

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Deniz Tasdemir, et al. Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). J Med Chem. 2002 Jan 17;45(2):529-32. [Content Brief]

Debromohymenialdisine Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Debromohymenialdisine75593-17-810Z-DebromohymenialdisineRafMEKRaf kinasesMitogen-activated protein kinase kinaseMAPKKMAP2Kpyrrole alkaloidRaf/MEK-1/MAPKsignalingproliferationdifferentiationInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks