Dehydro Nifedipine-¹³C,d₃  (Synonyms: BAY-b 4759-¹³C,d₃)

Dehydro Nifedipine-13C,d3 is a deuterated labeled Dehydro Nifedipine^[1]. Dehydro nifedipine (BAY-b 4759) is a metabolite of Nifedipine (HY-B0284). Nifedipine (BAY-a-1040) is a potent calcium channel blocker and an agent of choice for cardiac insufficiencies^[2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

271.25

C₉¹³CH₁₀D₃N₅O₄

325484-33-1

O=C(C([13C]([2H])([2H])[2H])=CN1[C@@H](C2)O[C@@H]([C@H]2N=[N+]=[N-])CO)NC1=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Dipanjan Goswami, et al. Method Development Challenges and Regulatory Expectation in Nifedipine. International Journal of Pharmacokinetics, Volume 2, 2017 - Issue 1.