Dehydroabietinol

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Dehydroabietinol is an abietane diterpenoid. Dehydroabietinol has kinase inhibition activity for spleen tyrosine kinase (SYK) with an IC₅₀ value of 46.4 μM. Dehydroabietinol can be used for the research of immune-mediated disease.

For research use only. We do not sell to patients.

Dehydroabietinol Chemical Structure

CAS No. : 3772-55-2

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	44.14 μM Compound: 2; DHO	Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured for 24 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured for 24 hrs by MTT assay	[PMID: 37122546]
HeLa	IC₅₀	13 μg/mL Compound: 5,dehydroabietinol	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 19892441]
HeLa	IC₅₀	15.7 μM Compound: 18-hydroxydehydroabietane	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 30684866]
HepG2	IC₅₀	45.7 μM Compound: 2; DHO	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured for 24 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured for 24 hrs by MTT assay	[PMID: 37122546]
Jurkat	IC₅₀	9.7 μg/mL Compound: 5,dehydroabietinol	Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay	[PMID: 19892441]
L02	IC₅₀	37.16 μM Compound: 2; DHO	Antiproliferative activity against human L02 cells assessed as reduction in cell viability measured for 24 hrs by MTT assay Antiproliferative activity against human L02 cells assessed as reduction in cell viability measured for 24 hrs by MTT assay	[PMID: 37122546]
MGC-803	IC₅₀	42.81 μM Compound: 2; DHO	Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured for 24 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured for 24 hrs by MTT assay	[PMID: 37122546]
T-24	IC₅₀	> 50 μM Compound: 2; DHO	Antiproliferative activity against human T24 cells assessed as reduction in cell viability measured for 24 hrs by MTT assay Antiproliferative activity against human T24 cells assessed as reduction in cell viability measured for 24 hrs by MTT assay	[PMID: 37122546]
Vero	IC₅₀	17 μg/mL Compound: 19	Concentration required for 50% inhibition of herpes simplex virus 2(HSV-2) using standard plaque reduction assay in vero cells Concentration required for 50% inhibition of herpes simplex virus 2(HSV-2) using standard plaque reduction assay in vero cells	10.1016/S0960-894X(01)80236-5
Vero	IC₅₀	38 μg/mL Compound: 5,dehydroabietinol	Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay	[PMID: 19892441]

In Vitro

Dehydroabietinol has kinase inhibition activity for SYK with an IC₅₀ value of 46.4 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

286.45

Formula

C₂₀H₃₀O

CAS No.

3772-55-2

SMILES

C[C@@]12C3=CC=C(C(C)C)C=C3CC[C@@]1([H])[C@@](C)(CCC2)CO

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jun-Bo Gao, et al. Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors. J Nat Prod. 2018 Apr 27;81(4):998-1006. [Content Brief]