Dehydroleucodine

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Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana. Dehydroleucodine is a mast cell stabilizer that inhibits tmast cell degranulation induced by compound 48/80. Dehydroleucodine inudces cells apoptosis, and has gastric ulcer inhibition and antileukemic effects.

For research use only. We do not sell to patients.

Dehydroleucodine Chemical Structure

CAS No. : 36150-07-9

Size	Stock	Quantity
5 mg	Get quote 3 - 4 weeks 4 - 5 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote 3 - 4 weeks 4 - 5 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa S3	IC₅₀	10 μM Compound: 1	Cytotoxicity against human HeLaS3 cells assessed as decrease in cell viability after 72 to 96 hrs by MTT assay Cytotoxicity against human HeLaS3 cells assessed as decrease in cell viability after 72 to 96 hrs by MTT assay	[PMID: 27057812]
KB	IC₅₀	5.3 μM Compound: 1	Cytotoxicity against human KB cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human KB cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 27057812]
MCF7	IC₅₀	5 μM Compound: 1	Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 to 96 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 to 96 hrs by MTT assay	[PMID: 27057812]

Molecular Weight

244.29

Formula

C₁₅H₁₆O₃

CAS No.

36150-07-9

SMILES

O=C(O[C@@]1([H])[C@@]2([H])CCC(C)=C3C(C=C(C)[C@@]31[H])=O)C2=C

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Paola E Ordóñez, et al. Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells. J Nat Prod. 2016 Apr 22;79(4):691-6. [Content Brief]

[2]. Mariano E Vera, et al. Activation of human leukemic mast cell line LAD2 is modulated by dehydroleucodine and xanthatin. Leuk Lymphoma. 2012 Sep;53(9):1795-803. [Content Brief]

[3]. Valeria V Costantino, et al. Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis. Cancer Lett. 2016 Mar 1;372(1):10-23. [Content Brief]