Desacetylvinblastine hydrazide (Synonyms: Deacetylvinblastine hydrazide; DAVLBH)

Cat. No.: HY-129880: FAQs
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Desacetylvinblastine hydrazide (Deacetylvinblastine hydrazide; DAVLBH) is an active component of EC145, a folate-targeted drug conjugate. Desacetylvinblastine hydrazide interferes with the formation of the mitotic spindle, and thus inhibits cell division and leads to cell death. Desacetylvinblastine hydrazide exhibits antitumor activity against folate receptor (FR)-positive tumor.

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Desacetylvinblastine hydrazide Chemical Structure

CAS No. : 55383-37-4

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Description	Desacetylvinblastine hydrazide (Deacetylvinblastine hydrazide; DAVLBH) is an active component of EC145, a folate-targeted drug conjugate. Desacetylvinblastine hydrazide interferes with the formation of the mitotic spindle, and thus inhibits cell division and leads to cell death. Desacetylvinblastine hydrazide exhibits antitumor activity against folate receptor (FR)-positive tumor^[1].
Molecular Weight	768.94
Formula	C₄₃H₅₆N₆O₇
CAS No.	55383-37-4
SMILES	CC[C@@]12[C@@]3([H])[C@@]4(CCN3CC=C2)C5=CC([C@@]6(C7=C(CC[N@@]8C[C@](C[C@](O)(C8)CC)([H])C6)C9=CC=CC=C9N7)C(OC)=O)=C(OC)C=C5N([C@@]4([H])[C@](O)([C@@H]1O)C(NN)=O)C
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (281 KB) Handling Instructions (2659 KB)
References	[1]. Li J, et al., Clinical pharmacokinetics and exposure-toxicity relationship of a folate-Vinca alkaloid conjugate EC145 in cancer patients. J Clin Pharmacol. 2009 Dec;49(12):1467-76. [Content Brief]

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	×		=		×
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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Desacetylvinblastine hydrazide55383-37-4Deacetylvinblastine hydrazide DAVLBHMicrotubule/TubulinvinblastineEC145vinca alkaloidInhibitorinhibitorinhibit

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Desacetylvinblastine hydrazide (Synonyms: Deacetylvinblastine hydrazide; DAVLBH)

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