Desoxo-narchinol A

Name: Desoxo-narchinol A
Brand: MedChemExpress
SKU: HY-N8435
Rating: 4.5 (1 reviews)

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Desoxo-narchinol A is an orally active and potent anti-inflammatory agent. Desoxo-narchinol A can be isolated from the roots and rhizomes of Nardostachys jatamansi. Desoxo-narchinol A can be used for septic shock and inflammatory diseases research.

For research use only. We do not sell to patients.

Desoxo-narchinol A Chemical Structure

CAS No. : 53859-06-6

Size	Stock	Quantity
1 mg	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

View All COX Isoform Specific Products:

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COX COX-1 COX-2 COX-3

View All NO Synthase Isoform Specific Products:

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nNOS iNOS eNOS

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
BV-2	IC₅₀	2.04 μM Compound: 3	Inhibition of lipopolysaccharide-induced IL-1beta production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA Inhibition of lipopolysaccharide-induced IL-1beta production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA	[PMID: 29221883]
BV-2	IC₅₀	2.05 μM Compound: 3	Inhibition of lipopolysaccharide-induced PGE2 production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs Inhibition of lipopolysaccharide-induced PGE2 production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs	[PMID: 29221883]
BV-2	IC₅₀	2.11 μM Compound: 3	Inhibition of lipopolysaccharide-induced TNFalpha production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA Inhibition of lipopolysaccharide-induced TNFalpha production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA	[PMID: 29221883]
BV-2	IC₅₀	3.48 μM Compound: 3	Inhibition of lipopolysaccharide-induced nitric oxide production in mouse BV2 cells assessed as reduction in nitrite level by Griess reaction based ELISA Inhibition of lipopolysaccharide-induced nitric oxide production in mouse BV2 cells assessed as reduction in nitrite level by Griess reaction based ELISA	[PMID: 29221883]
BV-2	IC₅₀	3.57 μM Compound: 3	Inhibition of lipopolysaccharide-induced IL6 production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA Inhibition of lipopolysaccharide-induced IL6 production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA	[PMID: 29221883]
Microglia	IC₅₀	3.18 μM Compound: 3	Inhibition of lipopolysaccharide-induced TNFalpha production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA Inhibition of lipopolysaccharide-induced TNFalpha production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA	[PMID: 29221883]
Microglia	IC₅₀	3.62 μM Compound: 3	Inhibition of lipopolysaccharide-induced IL6 production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA Inhibition of lipopolysaccharide-induced IL6 production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA	[PMID: 29221883]
Microglia	IC₅₀	4.96 μM Compound: 3	Inhibition of lipopolysaccharide-induced nitric oxide production in Sprague-Dawley rat primary microglia cells assessed as reduction in nitrite level by Griess reaction based ELISA Inhibition of lipopolysaccharide-induced nitric oxide production in Sprague-Dawley rat primary microglia cells assessed as reduction in nitrite level by Griess reaction based ELISA	[PMID: 29221883]
Microglia	IC₅₀	5.33 μM Compound: 3	Inhibition of lipopolysaccharide-induced PGE2 production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs Inhibition of lipopolysaccharide-induced PGE2 production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs	[PMID: 29221883]
Microglia	IC₅₀	5.84 μM Compound: 3	Inhibition of lipopolysaccharide-induced IL-1beta production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA Inhibition of lipopolysaccharide-induced IL-1beta production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA	[PMID: 29221883]
RAW264.7	IC₅₀	8.4 μM Compound: 4	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method	[PMID: 22079762]

In Vitro

Desoxo-narchinol A inhibits tissue injury and production of pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, in the liver and lung^[2].
Desoxo-narchinol A (0-500 nM, 24 h) inhibits the production of inflammatory mediators, such as iNOS and its derivative NO, COX-2, PGE2, IL-1β, IL-6 and TNF-α and H3 protein acetylation in murine peritoneal macrophages^[2].
Desoxo-narchinol A inhibits LPS-induced activation of p38 in murine macrophages^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Desoxo-narchinol A (0-0.5 mg/kg, IP, once) dramatically reduced mortality in a murine LPS-induced endotoxin shock model^[2].
Desoxo-narchinol A (50 mg/kg, PO, once) shows the oral bioavailability of 18.1% in rats and 28.4% in mice^[3]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

192.25

Formula

C₁₂H₁₆O₂

CAS No.

53859-06-6

SMILES

C[C@@]1([C@@H](C=C2)O)C(C2=O)=CCC[C@H]1C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Itokawa H, et al. Cytotoxic sesquiterpenes from Nardostachys chinensis. Chem Pharm Bull (Tokyo). 1993 Jun;41(6):1183-4. [Content Brief]

[2]. Shin JY, et al. Anti-inflammatory effect of desoxo-narchinol-A isolated from Nardostachys jatamansi against lipopolysaccharide. Int Immunopharmacol. 2015 Dec;29(2):730-738. [Content Brief]

[3]. Thapa SK, Upadhyay M, Kim TH, Shin S, Park SJ, Shin BS. Liquid Chromatography-Tandem Mass Spectrometry of Desoxo-Narchinol a and Its Pharmacokinetics and Oral Bioavailability in Rats and Mice. Molecules. 2019 May 28;24(11):2037. [Content Brief]