2. Neuronal Signaling
  3. Serotonin Transporter
  4. Desvenlafaxine succinate

Desvenlafaxine succinate  (Synonyms: O-Desmethylvenlafaxine succinate; Wy-45233 succinate)

Cat. No.: HY-16170
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Desvenlafaxine succinate, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine succinate (DVS) shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter.

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Desvenlafaxine succinate Chemical Structure

Desvenlafaxine succinate Chemical Structure

CAS No. : 448904-47-0

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Desvenlafaxine succinate Related Antibodies

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Description

Desvenlafaxine succinate, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine succinate (DVS) shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter[1][2].

IC50 & Target

IC50: 47.3 nM (hSERT), 531.3 nM (hNET)[1].
In Vitro

Desvenlafaxine succinate has the potential to inhibit CYP2D6, which could result in increased concentrations of drugs metabolized through this pathway. Desvenlafaxine succinate also induces CYP3A4, which could impact the metabolism of drugs metabolized via this enzyme[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Desvenlafaxine succinate Related Antibodies
In Vivo

Desvenlafaxine succinate (30 mg/kg, orally) significantly increases extracellular NE levels but had no effect on DA levels using microdialysis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male rats[1].
Dosage: 30 mg/kg.
Administration: Orally.
Result: Significantly increased extracellular NE levels compared with baseline in the male rat hypothalamus but had no effect on DA levels using microdialysis.
Molecular Weight

381.46

Formula

C20H31NO6
CAS No.
SMILES

O=C(O)CCC(O)=O.OC1=CC=C(C(C2(O)CCCCC2)CN(C)C)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Desvenlafaxine succinate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Desvenlafaxine448904-47-0O-DesmethylvenlafaxineWy-45233Wy45233Wy 45233Serotonin Transporter5-HTTSERTSLC6A4Inhibitorinhibitorinhibit

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