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Detajmium (Tachmalcor free base) is a Na?-channel blocker with activity to inhibit ventricular conduction and refractoriness. Detajmium (0.3μM) prolongs intraventricular conduction time comparable to propafenone (0.3μM) during sinus rhythm, but the time constant for reaching steady state during rapid ventricular pacing is significantly longer for Detajmium, indicating a unique temporal profile for its heart rate-dependent effects.

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Detajmium Chemical Structure

Detajmium Chemical Structure

CAS No. : 47719-70-0

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Description

Detajmium (Tachmalcor free base) is a Na?-channel blocker with activity to inhibit ventricular conduction and refractoriness. Detajmium (0.3μM) prolongs intraventricular conduction time comparable to propafenone (0.3μM) during sinus rhythm, but the time constant for reaching steady state during rapid ventricular pacing is significantly longer for Detajmium, indicating a unique temporal profile for its heart rate-dependent effects.

Molecular Weight

456.64

Formula

C27H42N3O3+
CAS No.
SMILES

OC1[C@]23[C@](N(C4=CC=CC=C43)C)([H])[C@@]5([H])[N+]6([C@@]([C@]1([H])[C@@]([C@@H]([C@H]6O)CC)([H])C5)([H])C2)CC(O)CN(CC)CC
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Detajmium Related Classifications

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Keywords:

Detajmium47719-70-0TachmalcorOthersInhibitorinhibitorinhibit

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