2. MAPK/ERK Pathway Stem Cell/Wnt PI3K/Akt/mTOR JAK/STAT Signaling Apoptosis
  3. ERK Akt STAT Apoptosis
  4. DETD-35

DETD-35 is an inhibitor of the MEK-ERK, Akt, and STAT3 signaling pathways, which promotes cancer cell apoptosis (Apoptosis) and reduces cancer cell resistance to Vemurafenib (HY-12057). The IC50 values of DETD-35 against wild-type and mutant melanoma cell lines B16-F10, MeWo, SK-MEL-2, A2058c, and A375c are 2.7, 6.0, 3.9, 3.1, and 2.5 μM, respectively. DETD-35 holds promise for research in the field of anti-melanoma therapy.

For research use only. We do not sell to patients.

DETD-35 Chemical Structure

DETD-35 Chemical Structure

CAS No. : 1836209-98-3

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DETD-35 Related Antibodies

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ERK ERK1 ERK2 ERK5 ERK8

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Akt Akt1 Akt2 Akt3

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STAT3 STAT5 STAT6 STAT1

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Description

DETD-35 is an inhibitor of the MEK-ERK, Akt, and STAT3 signaling pathways, which promotes cancer cell apoptosis (Apoptosis) and reduces cancer cell resistance to Vemurafenib (HY-12057). The IC50 values of DETD-35 against wild-type and mutant melanoma cell lines B16-F10, MeWo, SK-MEL-2, A2058c, and A375c are 2.7, 6.0, 3.9, 3.1, and 2.5 μM, respectively. DETD-35 holds promise for research in the field of anti-melanoma therapy[1].

IC50 & Target

Stat-3

 

Molecular Weight

444.48

Formula

C27H24O6
CAS No.
SMILES

O=C(O[C@H]1[C@H](C(C(O2)=O)=C)[C@@H]2CC(C(O3)=O)=C[C@H]3C/C(C)=C/1)CC4=CC=CC5=C4C=CC=C5
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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DETD-35 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DETD-351836209-98-3DETD35DETD 35ERKAktSTATApoptosisExtracellular signal regulated kinasesPKBProtein kinase BAnti-melanoma therapyInhibitorinhibitorinhibit

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