2. Vitamin D Related/Nuclear Receptor Autophagy
  3. Androgen Receptor Autophagy
  4. Deutenzalutamide-d3

Deutenzalutamide-d3  (Synonyms: Enzalutamide-d3; MDV3100-d3)

Cat. No.: HY-70002S Purity: 99.81%
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Deutenzalutamide (Enzalutamide-d3) is a developed deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells.

For research use only. We do not sell to patients.

Deutenzalutamide-d<sub>3</sub> Chemical Structure

Deutenzalutamide-d3 Chemical Structure

CAS No. : 1443331-82-5

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5 mg USD 270 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Deutenzalutamide-d3:

Deutenzalutamide-d3 Related Antibodies

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Description

Deutenzalutamide (Enzalutamide-d3) is a developed deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
Potential advantages of deuterated compounds:
(1) Extend the half-life in vivo. Deuterated compounds may be able to prolong the pharmacokinetic characteristics of the compound, that is, prolong the half-life in vivo. This can improve compound safety, efficacy and tolerability, and increase ease of administration.
(2) Improve oral bioavailability. Deuterated compounds may reduce the degree of unwanted metabolism (first-pass metabolism) in the gut wall and liver, allowing a greater proportion of the unmetabolized drug to reach its target site of action. High bioavailability determines its activity at low doses and better tolerance.
(3) Improve metabolic characteristics. Deuterated compounds may reduce the formation of toxic or reactive metabolites and improve drug metabolism.
(4) Improve drug safety. Deuterated compounds may reduce or eliminate adverse side effects of pharmaceutical compounds and are safe.
(5) Preserve the therapeutic properties. Deuterated compounds are expected to retain similar biochemical potency and selectivity to hydrogen analogs in previous studies.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Deutenzalutamide-d3 Related Antibodies
Molecular Weight

467.45

Formula

C21H13D3F4N4O2S
CAS No.
Unlabeled CAS

915087-33-1
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC([2H])([2H])[2H])C1=CC=C(N(C(N2C3=CC=C(C#N)C(C(F)(F)F)=C3)=S)C(C)(C)C2=O)C=C1F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (53.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1393 mL 10.6963 mL 21.3927 mL
5 mM 0.4279 mL 2.1393 mL 4.2785 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1393 mL 10.6963 mL 21.3927 mL 53.4817 mL
5 mM 0.4279 mL 2.1393 mL 4.2785 mL 10.6963 mL
10 mM 0.2139 mL 1.0696 mL 2.1393 mL 5.3482 mL
15 mM 0.1426 mL 0.7131 mL 1.4262 mL 3.5654 mL
20 mM 0.1070 mL 0.5348 mL 1.0696 mL 2.6741 mL
25 mM 0.0856 mL 0.4279 mL 0.8557 mL 2.1393 mL
30 mM 0.0713 mL 0.3565 mL 0.7131 mL 1.7827 mL
40 mM 0.0535 mL 0.2674 mL 0.5348 mL 1.3370 mL
50 mM 0.0428 mL 0.2139 mL 0.4279 mL 1.0696 mL
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Deutenzalutamide-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Deutenzalutamide-d31443331-82-5Enzalutamide-d3MDV3100-d3Androgen ReceptorAutophagydeuteriumcancerLNCaPprostatecellsInhibitorinhibitorinhibit

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