DGDG

Cat. No.: HY-143693: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

DGDG, a chloroplast lipid, is a bilayer-forming lipid. DGDG is important for photosynthesis, and can be used for drug delivery.

For research use only. We do not sell to patients.

DGDG Chemical Structure

CAS No. : 63142-69-8

Size	Price	Stock
1 mg	USD 450	Ask For Quote & Lead Time
5 mg	USD 1150	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
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Description

DGDG, a chloroplast lipid, is a bilayer-forming lipid. DGDG is important for photosynthesis, and can be used for drug delivery^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Vero	CC₅₀	> 100 μg/mL Compound: 1	Cytotoxicity against african green monkey Vero cells after 72 hrs by resazurin dye-based fluorimetric analysis Cytotoxicity against african green monkey Vero cells after 72 hrs by resazurin dye-based fluorimetric analysis	[PMID: 22348826]

In Vitro

Apart from facilitating the photosynthesis light reaction in the thylakoid membrane, DGDG is important for maintaining chloroplast morphology and for plant survival under abiotic stresses such as phosphate starvation and freezing. During phosphate limitation, the amounts of DGDG increase in the plastids of plants, and DGDG is exported to extraplastidial membranes to replace phospholipids^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

937.20

Formula

C₅₁H₈₄O₁₅

CAS No.

63142-69-8

Appearance

Oil

Color

Brown to black

SMILES

OC[C@H]([C@@H]([C@@H]([C@H]1O)O)O)O[C@@H]1OC[C@H]2O[C@H]([C@@H]([C@H]([C@H]2O)O)O)OC[C@H](OC(CCCCCCC/C=C\C/C=C\C/C=C\CC)=O)COC(CCCCCCC/C=C\C/C=C\C/C=C\CC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (106.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0670 mL	5.3350 mL	10.6701 mL
5 mM	0.2134 mL	1.0670 mL	2.1340 mL
10 mM	0.1067 mL	0.5335 mL	1.0670 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (2.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (2.67 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (267 KB) SDS (252 KB)

COA (241 KB)

Handling Instructions (2659 KB)

References

[1]. Hsou-Min Li, et al. Chloroplast Galactolipids: The Link Between Photosynthesis, Chloroplast Shape, Jasmonates, Phosphate Starvation and Freezing Tolerance. Plant Cell Physiol. 2018 Jun 1;59(6):1128-1134. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0670 mL	5.3350 mL	10.6701 mL	26.6752 mL
	5 mM	0.2134 mL	1.0670 mL	2.1340 mL	5.3350 mL
	10 mM	0.1067 mL	0.5335 mL	1.0670 mL	2.6675 mL
	15 mM	0.0711 mL	0.3557 mL	0.7113 mL	1.7783 mL
	20 mM	0.0534 mL	0.2668 mL	0.5335 mL	1.3338 mL
	25 mM	0.0427 mL	0.2134 mL	0.4268 mL	1.0670 mL
	30 mM	0.0356 mL	0.1778 mL	0.3557 mL	0.8892 mL
	40 mM	0.0267 mL	0.1334 mL	0.2668 mL	0.6669 mL
	50 mM	0.0213 mL	0.1067 mL	0.2134 mL	0.5335 mL
	60 mM	0.0178 mL	0.0889 mL	0.1778 mL	0.4446 mL
	80 mM	0.0133 mL	0.0667 mL	0.1334 mL	0.3334 mL
	100 mM	0.0107 mL	0.0534 mL	0.1067 mL	0.2668 mL

DGDG Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DGDG63142-69-8Liposomechloroplast lipidsdrug deliverybilayer-forming lipidphotosynthesisInhibitorinhibitorinhibit

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