2. Metabolic Enzyme/Protease Anti-infection
  3. Dihydrofolate reductase (DHFR) Bacterial
  4. DHFR-IN-17

DHFR-IN-17 (compound j9) is an oral active SaDHFR inhibitor with the IC50 of 0.97 nM. DHFR-IN-17 shows antibacterial activity against S. aureus with the minimum inhibitory concentration of 0.031 μg/mL.

For research use only. We do not sell to patients.

DHFR-IN-17 Chemical Structure

DHFR-IN-17 Chemical Structure

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DHFR-IN-17 Related Antibodies

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Description

DHFR-IN-17 (compound j9) is an oral active SaDHFR inhibitor with the IC50 of 0.97 nM. DHFR-IN-17 shows antibacterial activity against S. aureus with the minimum inhibitory concentration of 0.031 μg/mL[1].

In Vivo

DHFR-IN-17 (compound j9) (2、5 and 10mg/kg, oral gavagefor 3 consecutive days) alleviates the skin infection damage in MRSA-induced epidermal infections in C57 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MRSA-induced epidermal infections in C57 mice[1]
Dosage: 2、5 and 10mg/kg
Administration: Oral gavagefor 3 consecutive days
Result: Alleviates the skin infection damage.
Molecular Weight

440.28

Formula

C17H21IN4O2
SMILES

CC(C1=C(C=C(C(OCC2CC2)=C1)I)OC3=CN=C(N=C3N)N)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DHFR-IN-17 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHFR-IN-17Dihydrofolate reductase (DHFR)BacterialStaphylococcus aureus infectionantibacterialInhibitorinhibitorinhibit

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HY-162358
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