2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Dihydroorotate Dehydrogenase DNA/RNA Synthesis
  4. DHODH-IN-20

DHODH-IN-20 (Compound 133) is a potent inhibitor of DHODH. DHODH is present in the inner membrane of human mitochondria and is an iron-containing flavin-dependent enzyme. DHODH-IN-20 inhibits tumor growth. DHODH-IN-20 has the potential for the research of acute myelogenous leukemia.

For research use only. We do not sell to patients.

DHODH-IN-20 Chemical Structure

DHODH-IN-20 Chemical Structure

CAS No. : 2639835-02-0

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DHODH-IN-20 Related Antibodies

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Description

DHODH-IN-20 (Compound 133) is a potent inhibitor of DHODH. DHODH is present in the inner membrane of human mitochondria and is an iron-containing flavin-dependent enzyme. DHODH-IN-20 inhibits tumor growth. DHODH-IN-20 has the potential for the research of acute myelogenous leukemia[1].

Cellular Effect
Cell Line Type Value Description References
MOLM-13 IC50
0.02 nM
Compound: 133
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability measured for 72 hrs by cell titer glo assay
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability measured for 72 hrs by cell titer glo assay
[PMID: 35178168]
Molecular Weight

479.47

Formula

C24H25F4N3O3
CAS No.
SMILES

O=C(NC1=CC=CC=C1C)C2=CC(F)=C(C3=CN(C)C(C(C)(O)C)=N3)C=C2O[C@@H](C)C(F)(F)F
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DHODH-IN-20 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHODH-IN-202639835-02-0Dihydroorotate DehydrogenaseDNA/RNA SynthesisDHODHmitochondriairon-containingflavin-dependent enzymetumor growthacute myelogenous leukemiaInhibitorinhibitorinhibit

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