2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Dihydroorotate Dehydrogenase DNA/RNA Synthesis
  4. DHODH-IN-3

DHODH-IN-3 (compound 3) is a potent inhibitor of Human Dihydroorotate Dehydrogenases (HsDHODH) with an IC50 value of 261 nM. DHODH-IN-3 binds to the the ubiquinone binding cavities in DHODH with a Kiapp of 32 nM. DHODH-IN-3 has the potential for malaria treatment.

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DHODH-IN-3 Chemical Structure

DHODH-IN-3 Chemical Structure

CAS No. : 1148126-04-8

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DHODH-IN-3 Related Antibodies

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Description

DHODH-IN-3 (compound 3) is a potent inhibitor of Human Dihydroorotate Dehydrogenases (HsDHODH) with an IC50 value of 261 nM. DHODH-IN-3 binds to the the ubiquinone binding cavities in DHODH with a Kiapp of 32 nM. DHODH-IN-3 has the potential for malaria treatment[1].

IC50 & Target

IC50: 261 nM (HsDHODH)[1]
In Vitro

DHODH-IN-3 (compound 3) show good inhibitory effects on HsDHODH with IC50 value of 261 nM. It binds to HsDHODH with a Kiapp value of 32 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DHODH-IN-3 Related Antibodies
Molecular Weight

312.75

Formula

C17H13ClN2O2
CAS No.
SMILES

C/C(O)=C(C#N)/C(NC1=CC=C(C2=CC=CC=C2)C=C1Cl)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DHODH-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHODH-IN-31148126-04-8Dihydroorotate DehydrogenaseDNA/RNA SynthesisDHODHmalariaHsDHODHInhibitorinhibitorinhibit

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