2. Metabolic Enzyme/Protease
  3. NADPH Oxidase
  4. Diapocynin

Diapocynin  (Synonyms: Dehydrodiacetovanillone)

Cat. No.: HY-121097
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Diapocynin (Dehydrodiacetovanillone), a dimeric derivative of Apocynin, is an orally active NADPH oxidase inhibitor. Diapocynin has anti-inflammatory, neuroprotection and antioxidant activities.

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Diapocynin Chemical Structure

Diapocynin Chemical Structure

CAS No. : 29799-22-2

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Based on 1 publication(s) in Google Scholar

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Description

Diapocynin (Dehydrodiacetovanillone), a dimeric derivative of Apocynin, is an orally active NADPH oxidase inhibitor. Diapocynin has anti-inflammatory, neuroprotection and antioxidant activities[1].

In Vivo

Diapocynin (300 mg/kg; p.o.; every 12 hours for 72 hours) significantly rescues DFP-induced motor impairment, attenuates epileptiform spiking during the first 72h post-DFP. Diapocynin significantly reduces DFP-induced reactive astrogliosis, neurodegeneration, GP91phox, glutathiolated protein, serum nitrite, or pro-inflammatory cytokines and chemokines such as interleukins (IL) IL-1α, IL-6, IL-2, IL-17A, Leptin, IP-10 in the hippocampus[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats (200 g; 7-8 weeks old) injected with Diisopropylfluorophosphate (DFP)[1]
Dosage: 300 mg/kg
Administration: p.o.; every 12 hours for 72 hours
Result: Significantly rescued DFP-induced motor impairment.
Molecular Weight

330.33

Formula

C18H18O6
CAS No.
SMILES

COC1=CC(C(C)=O)=CC(C2=C(O)C(OC)=CC(C(C)=O)=C2)=C1O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Diapocynin Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diapocynin29799-22-2DehydrodiacetovanilloneNADPH OxidaseNOXNADPH oxidase inhibitordimericApocyninorally activeanti-inflammatoryneuroprotectionantioxidantInhibitorinhibitorinhibit

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