Dichlorphenamide disodium (Synonyms: Diclofenamide disodium)

Cat. No.: HY-B0397A: FAQs
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Dichlorphenamide (Diclofenamide) disodium is an orally active, specific, carbonic anhydrase inhibitor. Dichlorphenamide can reduce intraocular pressure by inhibiting the secretion of water from the eye. Dichlorphenamide can be used for glaucoma research.

For research use only. We do not sell to patients.

Dichlorphenamide disodium Chemical Structure

CAS No. : 76382-13-3

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Other In-stock Forms of Dichlorphenamide disodium:

Dichlorphenamide

Other Forms of Dichlorphenamide disodium:

Dichlorphenamide In-stock

1 Publications Citing Use of MCE Dichlorphenamide disodium

•EMBO Rep. 2022 Apr 11;e53932. [Abstract]

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CA CA I CA Ⅱ CA Ⅸ CA XII

Biological Activity
Purity & Documentation
References
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Description

In Vivo

Dichlorphenamide disodium can reduce IOP locally in male albino rabbits^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male albino rabbits (approximately 2.5 kg)^[1]
Dosage:	50 μL 10% aqueous solutions of dichlorphenamide sodium or 2 mg/kg, 6 mg/kg
Administration:	Eye drop of 50 μL or oral gavage of 2 mg/kg or 6 mg/kg，5 hours
Result:	Showed significant decrease in IOP at 30 min by instilling into eyes and decrease in IOP only at 1 h by orally after drug administration. And demonstrated that drug levels were significantly higher in the iris ciliary body and lower in the serum by instilling compared to oral administration.

Clinical Trial

Molecular Weight

351.14

Formula

C₆H₆Cl₂N₂Na₂O₄S₂

CAS No.

76382-13-3

SMILES

O=S(C1=CC(Cl)=C(Cl)C(S(=O)(N)=O)=C1)(N)=O.[Na].[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. V J Lotti, et al. Topical ocular hypotensive activity and ocular penetration of dichlorphenamide sodium in rabbits. Graefes Arch Clin Exp Ophthalmol. 1984;222(1):13-9. doi: 10.1007/BF02133771. [Content Brief]

Dichlorphenamide disodium Related Classifications

Neurological Disease

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dichlorphenamide disodium76382-13-3Diclofenamide disodiumCarbonic AnhydraseCarbonate dehydrataseCarbonic anhydrase inhibitorGlaucomaEyesInhibitorinhibitorinhibit

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