Dihydrodiol-Ibrutinib-d₅ (Synonyms: PCI-45227-d₅)

Cat. No.: HY-100659S: FAQs
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Dihydrodiol-Ibrutinib-d5 is the deuterium labeled Dihydrodiol-Ibrutinib (HY-100659). Dihydrodiol-Ibrutinib is a dihydrodiol active metabolite of Ibrutinib (HY-10997), has inhibitory activity towards BTK approximately 15 times lower than that of ibrutinib.

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Dihydrodiol-Ibrutinib-d<sub>5</sub> Chemical Structure

Dihydrodiol-Ibrutinib-d₅ Chemical Structure

CAS No. : 2068022-09-1

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1 mg		Get quote	Estimated Time of Arrival: December 31

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Other Forms of Dihydrodiol-Ibrutinib-d₅:

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Description	Dihydrodiol-Ibrutinib-d5 is the deuterium labeled Dihydrodiol-Ibrutinib (HY-100659). Dihydrodiol-Ibrutinib is a dihydrodiol active metabolite of Ibrutinib (HY-10997), has inhibitory activity towards BTK approximately 15 times lower than that of ibrutinib^[1].
Molecular Weight	479.54
Formula	C₂₅H₂₁D₅N₆O₄
CAS No.	2068022-09-1
Unlabeled CAS	1226872-27-0
SMILES	NC1=C2C(N([C@@]3([H])CN(CCC3)C(C(O)CO)=O)N=C2C4=CC=C(C=C4)OC5=C([2H])C([2H])=C([2H])C([2H])=C5[2H])=NC=N1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (273 KB) Handling Instructions (2659 KB)
References	[1]. Sridhar Veeraraghavan,et al. Simultaneous quantification of lenalidomide, ibrutinib and its active metabolite PCI-45227 in rat plasma by LC-MS/MS: application to a pharmacokinetic study. J Pharm Biomed Anal [Content Brief]

Dihydrodiol-Ibrutinib-d₅ Related Classifications

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dihydrodiol-Ibrutinib-d₅2068022-09-1PCI-45227-d₅BtkIsotope-Labeled CompoundsBruton tyrosine kinaseBTKmetabolitedihydrodiolInhibitorinhibitorinhibit

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Dihydrodiol-Ibrutinib-d5 (Synonyms: PCI-45227-d5)

Other Forms of Dihydrodiol-Ibrutinib-d5:

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