Dimethothiazine hydrochloride  (Synonyms: Dimetotiazine hydrochloride; Fonazine hydrochloride)

Dimethothiazine hydrochloride is an orally active tricyclic anti-histamine, anti-5-HT agent with a high activity against decerebrate rigidity, a little sedative activity and little soporific action. Dimethothiazine hydrochloride can reduce or abolish the effects of both static and dynamic fusimotor activity on the muscle spindle in decerebrate cat. Dimethothiazine hydrochloride can be used to research hemicrania and spasticity^[1][2][3].

428.01

C₁₉H₂₆ClN₃O₂S₂

34396-64-0

O=S(C1=CC=C2SC3=C(N(CC(C)N(C)C)C2=C1)C=CC=C3)(N(C)C)=O.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Nattero G, et al. Use of dimethothiazine in the prevention of hemicrania. Minerva Med. 1977 Mar 17;68(13):839-45.  [Content Brief]

  [2]. Maxwell DR, Rhodes KF. The effects of dimethothiazine on muscle spindle activity in the decerebrate cat. Br J Pharmacol. 1970 Jul;39(3):520-32.  [Content Brief]

  [3]. Griffiths MI, et al. The use of dimethothiazine in the treatment of childhood cerebral palsy. Dev Med Child Neurol. 1973 Feb;15(1):25-32.  [Content Brief]