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Dinaline  (Synonyms: GOE 1734; PD 104 208; NSC 328786)

Cat. No.: HY-W326094
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Dinaline (GOE 1734; PD 104 208; NSC 328786) is a potent and orally activity anticancer agent. Dinaline shows cytotoxicity and antitumor activity. Dinaline has the potential for the research of colorectal cancer.

For research use only. We do not sell to patients.

Dinaline Chemical Structure

Dinaline Chemical Structure

CAS No. : 58338-59-3

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Dinaline Related Antibodies

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Description

Dinaline (GOE 1734; PD 104 208; NSC 328786) is a potent and orally activity anticancer agent. Dinaline shows cytotoxicity and antitumor activity. Dinaline has the potential for the research of colorectal cancer[1].

In Vitro

Dinaline (0.47-15 µg/mL; 48, 27 h) shows cytotoxicity for SW707, SW948 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dinaline Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: SW707, SW948 cells
Concentration: 0.47, 0.95, 1.9, 3.8, 7.5, 15 µg/mL
Incubation Time: 48, 72 h
Result: Inhibited cell growth with IC50s of 2.2, 1.0 µg/mL at 48 h and 1.2, 0.8 µg/mL at 72 h for SW707, SW948 cells, respectively.
In Vivo

Dinaline (5.9, 7.7, 10 mg/kg; p.o.; 5 days per week for 10 weeks) inhibits tumor growth in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 140-160 g, male Sprague-Dawley rats[1]
Dosage: 5.9, 7.7, 10 mg/kg
Administration: P.o.; 5 days per week for 10 weeks
Result: Showed significant tumor growth inhibition in a dose-dependent manner with the ratio of median tumor volume of (T/C%) values of 0.4, 16 and 10.6 at 10, 7.7 and 5.9 mg/kg respectively.
Molecular Weight

227.26

Formula

C13H13N3O
CAS No.
SMILES

O=C(C1=CC=C(C=C1)N)NC2=C(N)C=CC=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Dinaline Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dinaline58338-59-3GOE 1734 PD 104 208 NSC 328786GOE1734GOE-1734NSC328786NSC 328786NSC-328786Othersorally activitycytotoxicitycolorectal cancerSW707SW948 cellsInhibitorinhibitorinhibit

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