Dinotefuran-d₃  (Synonyms: MTI-446-d₃)

Dinotefuran-d₃ is the deuterium labeled Dinotefuran[1]. Dinotefuran is an insecticide of the neonicotinoid class, its mechanism of action involves disruption of the insect's nervous system by inhibiting nicotinic acetylcholine receptors[2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

205.23

C₇H₁₁D₃N₄O₃

2934813-27-9

165252-70-0

[2H]C([2H])([2H])N/C(N[N+]([O-])=O)=N\CC1CCOC1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Liu T, et al. Biochemical and genetic toxicity of dinotefuran on earthworms (Eisenia fetida). Chemosphere. 2017 Jun;176:156-164.  [Content Brief]