2. Anti-infection
  3. SARS-CoV
  4. Direct Violet 1

Direct Violet 1, an azo dye, is a textile dye. Direct Violet 1 is also the protein-protein interaction (PPI) between the SARS-CoV-2 spike protein and ACE2 inhibitor with IC50s of 1.47-2.63 μM.

For research use only. We do not sell to patients.

Direct Violet 1 Chemical Structure

Direct Violet 1 Chemical Structure

CAS No. : 2586-60-9

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1 g USD 30 In-stock
5 g USD 85 In-stock
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50 g   Get quote  

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Based on 1 publication(s) in Google Scholar

Direct Violet 1 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

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Description

Direct Violet 1, an azo dye, is a textile dye. Direct Violet 1 is also the protein-protein interaction (PPI) between the SARS-CoV-2 spike protein and ACE2 inhibitor with IC50s of 1.47-2.63 μM[1][2].

IC50 & Target

IC50: 1.47 µM (SARS-CoV-2-S-RBD binding to ACE2); 2.63 µM (SARS-CoV-S1S2 binding to ACE2); 2.11 µM (TNF-R1-TNFα binding)[1]
In Vitro

Direct Violet 1 inhibits SARS-CoV-2-S-RBD binding to human ACE2, inhibits SARS-CoV-S1S2 binding to ACE2, and inhibits TNF-R1 binding to TNFα with IC50 values of 1.47 μM, 2.63 μM, and 2.11 μM, respectively[1].
Direct Violet 1 inhibits SARS-CoV-2 pseudovirus entry into hACE2 expressing host cells in a concentration-dependent manner with an IC50 of 35.8 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Direct Violet 1 Related Antibodies
Molecular Weight

728.66

Formula

C32H22N6Na2O8S2
CAS No.
Appearance

Solid

Color

Off-white to brown

SMILES

O=S(C1=CC(O)=C2C(/N=N/C3=CC=C(C4=CC=C(/N=N/C5=C(N)C=CC6=CC(S(=O)(O[Na])=O)=CC(O)=C56)C=C4)C=C3)=C(N)C=CC2=C1)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 62.5 mg/mL (85.77 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3724 mL 6.8619 mL 13.7238 mL
5 mM 0.2745 mL 1.3724 mL 2.7448 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.3724 mL 6.8619 mL 13.7238 mL 34.3096 mL
5 mM 0.2745 mL 1.3724 mL 2.7448 mL 6.8619 mL
10 mM 0.1372 mL 0.6862 mL 1.3724 mL 3.4310 mL
15 mM 0.0915 mL 0.4575 mL 0.9149 mL 2.2873 mL
20 mM 0.0686 mL 0.3431 mL 0.6862 mL 1.7155 mL
25 mM 0.0549 mL 0.2745 mL 0.5490 mL 1.3724 mL
30 mM 0.0457 mL 0.2287 mL 0.4575 mL 1.1437 mL
40 mM 0.0343 mL 0.1715 mL 0.3431 mL 0.8577 mL
50 mM 0.0274 mL 0.1372 mL 0.2745 mL 0.6862 mL
60 mM 0.0229 mL 0.1144 mL 0.2287 mL 0.5718 mL
80 mM 0.0172 mL 0.0858 mL 0.1715 mL 0.4289 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Direct Violet 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Direct Violet 12586-60-9Direct Violet1Direct Violet-1SARS-CoVSARS coronavirusCOVID-19antiviralSARS-CoV-2ACE2SARS-CoV-S1S2TNF-R1TNFαpikeInhibitorinhibitorinhibit

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