2. Apoptosis
  3. Apoptosis
  4. Diselaginellin B

Diselaginellin B (compound 2) is a natural product isolated from Selaginella Pulvinata, which exhibits anti-proliferative, apoptosis-inducing and antimetastatic activities against human carcinoma hepatocellular cells.

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Diselaginellin B Chemical Structure

Diselaginellin B Chemical Structure

CAS No. : 1835299-12-1

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Diselaginellin B Related Antibodies

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Description

Diselaginellin B (compound 2) is a natural product isolated from Selaginella Pulvinata, which exhibits anti-proliferative, apoptosis-inducing and antimetastatic activities against human carcinoma hepatocellular cells[1].

In Vitro

Diselaginellin B (2.5-10 μM) exhibits cytotoxic activity against SMMC-7721 cells, with an IC50 of 9.0 μM, and induces apoptosis in a concentration-dependent manner, by upregulating levels of DLD and inhibiting expressions of COX-1/2 and NNMT[1].
Diselaginellin B (0.5-2 μM) downregulates the TSPAN8 and MAGP2, inhibits the angiogenesis and reduces the cancer cells migration and invasion in SMMC-7721[1].
Diselaginellin B (2.5-5 μM) arrests the cells at G1 phase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Diselaginellin B Related Antibodies

Cell Invasion Assay[1]

Cell Line: SMMC-7721
Concentration: 0.5-2 μM
Incubation Time: 48 h
Result: Reduced the cancer cells migration and invasion in a dose-dependent manner.

Real Time qPCR[1]

Cell Line: SMMC-7721
Concentration: 8 μM
Incubation Time: 3 days
Result: Upregulated DLD, decreased expressions of COX-1/2, NNMT, TSPAN8 and MAGP2
Molecular Weight

1007.09

Formula

C68H46O9
CAS No.
SMILES

OC1=CC=C(/C(C2=C(C#CC3=CC=C(OCC4=CC=C(C5=CC=C(O)C=C5)C(/C(C6=CC=C(O)C=C6)=C(C=C7)/C=CC7=O)=C4C#CC8=CC=C(O)C=C8)C=C3)C(CO)=CC=C2C9=CC=C(O)C=C9)=C(C=C%10)\C=CC%10=O)C=C1
Structure Classification
Initial Source
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Diselaginellin B Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diselaginellin B1835299-12-1ApoptosisSMMC-7721HCCSelaginella PulvinataInhibitorinhibitorinhibit

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