2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. Divarasib adipate

Divarasib adipate  (Synonyms: GDC-6036 adipate)

Cat. No.: HY-145928B
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Divarasib (GDC-6036) adipate is an orally bioavailable, highly potent, and selective KRAS G12C inhibitor with an IC50 of <0.01 μM. Divarasib covalently binds to the switch II (SW-II) pocket of KRAS G12C and irreversibly locks it in the inactive GDP-bound state.

For research use only. We do not sell to patients.

Divarasib adipate Chemical Structure

Divarasib adipate Chemical Structure

CAS No. : 2762240-36-6

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Other Forms of Divarasib adipate:

Divarasib adipate Related Antibodies

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Description

Divarasib (GDC-6036) adipate is an orally bioavailable, highly potent, and selective KRAS G12C inhibitor with an IC50 of <0.01 μM. Divarasib covalently binds to the switch II (SW-II) pocket of KRAS G12C and irreversibly locks it in the inactive GDP-bound state[1][2].

Molecular Weight

768.20

Formula

C35H42ClF4N7O6
CAS No.
SMILES

NC1=N[C@]([C@]2=C(C=C3C(N=C(N=C3N4[C@H](CN(CC4)C(C=C)=O)C)OC[C@H]5N(CCC5)C)=C2F)Cl)=C(C(C)=C1)C(F)(F)F.O=C(CCCCC(O)=O)O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Divarasib adipate Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Divarasib2762240-36-6GDC-6036GDC6036GDC 6036RasK-Ras G12CHCC1171NSCLC NCI-H2030.X1.1 cellInhibitorinhibitorinhibit

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