DL-Histidine-d₃

Name: DL-Histidine-d 3
Brand: MedChemExpress
SKU: HY-W010209S2
Rating: 4.5 (1 reviews)

Cat. No.: HY-W010209S2 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

DL-Histidine-d₃ is the deuterium labeled DL-Histidine.

For research use only. We do not sell to patients.

DL-Histidine-d<sub>3</sub> Chemical Structure

DL-Histidine-d₃ Chemical Structure

CAS No. : 344299-50-9

Size	Price	Stock	Quantity
1 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of DL-Histidine-d₃:

DL-Histidine Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

DL-Histidine-d₃ is the deuterium labeled DL-Histidine.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

158.17

Formula

C₆H₆D₃N₃O₂

CAS No.

344299-50-9

Unlabeled CAS

4998-57-6

Appearance

Solid

Color

Off-white to light brown

SMILES

OC(C(N)([2H])C([2H])([2H])C1=CN=CN1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 25 mg/mL (158.06 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.3223 mL	31.6116 mL	63.2231 mL
5 mM	1.2645 mL	6.3223 mL	12.6446 mL
10 mM	0.6322 mL	3.1612 mL	6.3223 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (253 KB) HNMR (169 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / H₂O	1 mM	6.3223 mL	31.6116 mL	63.2231 mL	158.0578 mL
	5 mM	1.2645 mL	6.3223 mL	12.6446 mL	31.6116 mL
	10 mM	0.6322 mL	3.1612 mL	6.3223 mL	15.8058 mL
	15 mM	0.4215 mL	2.1074 mL	4.2149 mL	10.5372 mL
	20 mM	0.3161 mL	1.5806 mL	3.1612 mL	7.9029 mL
	25 mM	0.2529 mL	1.2645 mL	2.5289 mL	6.3223 mL
	30 mM	0.2107 mL	1.0537 mL	2.1074 mL	5.2686 mL
	40 mM	0.1581 mL	0.7903 mL	1.5806 mL	3.9514 mL
	50 mM	0.1264 mL	0.6322 mL	1.2645 mL	3.1612 mL
	60 mM	0.1054 mL	0.5269 mL	1.0537 mL	2.6343 mL
	80 mM	0.0790 mL	0.3951 mL	0.7903 mL	1.9757 mL
	100 mM	0.0632 mL	0.3161 mL	0.6322 mL	1.5806 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.