2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker
  4. DNA crosslinker 4 dihydrochloride

DNA crosslinker 4 (dihydrochloride) is a potent DNA minor groove binder. DNA crosslinker 4 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 4 (dihydrochloride) can be used for researching anticancer.

For research use only. We do not sell to patients.

DNA crosslinker 4 dihydrochloride Chemical Structure

DNA crosslinker 4 dihydrochloride Chemical Structure

CAS No. : 2761734-23-8

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DNA crosslinker 4 dihydrochloride Related Antibodies

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Description

DNA crosslinker 4 (dihydrochloride) is a potent DNA minor groove binder. DNA crosslinker 4 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 4 (dihydrochloride) can be used for researching anticancer[1].

IC50 & Target

IC50: 21 ± 1 μM in A2780 cells[1]
Cellular Effect
Cell Line Type Value Description References
A2780 IC50
21 μM
Compound: 2
Cytotoxicity against human A2780 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
Cytotoxicity against human A2780 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
[PMID: 35300077]
In Vitro

DNA crosslinker 4 (dihydrochloride) (compound 2) (100 μM; 48 h or 96 h) exhibits inhibitory activity against NCI-H460, A2780 and MCF-7[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DNA crosslinker 4 dihydrochloride Related Antibodies

Cell Viability Assay

Cell Line: NCI-H460, A2780 and MCF-7[1]
Concentration: 100 μM
Incubation Time: 48 h (NCI-H460) and 96 h (A2780 and MCF-7)
Result: Exhibited inhibitory activity against NCI-H460, A2780 and MCF-7 with inhibition percentage of 34%, 59% and 22% at 100 μM; and showed an IC50 value of 21 ± 1 μM in A2780 cells.
Molecular Weight

415.32

Formula

C16H24Cl2N8O
CAS No.
SMILES

CC1=CC(N(N=C1CNC(N)=N)CC2=CC=C(C=C2)CNC(N)=N)=O.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DNA crosslinker 4 dihydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DNA crosslinker 42761734-23-8DNA crosslinker4DNA crosslinker-4DNA Alkylator/CrosslinkerAnticancerDNAMinor grooveNCI-H460A2780MCF-7Inhibitorinhibitorinhibit

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DNA crosslinker 4 dihydrochloride
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