2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. DNA Gyrase-IN-15

DNA Gyrase-IN-15 (Compound 11) is an antimicrobial agent and inhibitor of DHPS and DNA gyrase, with IC50s of 1.73 and 0.07 µM, respectively. DNA Gyrase-IN-15 shows antimicrobial activity against Enterococcus faecalis (MIC of 15.62 µg/mL), Acinetobacter baumannii, Enterobacter species (MIC of 7.81 µg/mL), Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus. DNA Gyrase-IN-15 also shows antibiofilm activity against Enterococcus faecalis.

For research use only. We do not sell to patients.

DNA Gyrase-IN-15 Chemical Structure

DNA Gyrase-IN-15 Chemical Structure

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DNA Gyrase-IN-15 Related Antibodies

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Description

DNA Gyrase-IN-15 (Compound 11) is an antimicrobial agent and inhibitor of DHPS and DNA gyrase, with IC50s of 1.73 and 0.07 µM, respectively. DNA Gyrase-IN-15 shows antimicrobial activity against Enterococcus faecalis (MIC of 15.62 µg/mL), Acinetobacter baumannii, Enterobacter species (MIC of 7.81 µg/mL), Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus. DNA Gyrase-IN-15 also shows antibiofilm activity against Enterococcus faecalis[1].

IC50 & Target

DHPS and DNA gyrase: IC50 of 1.73 and 0.07 µM, respectively.
Molecular Weight

582.69

Formula

C31H26N4O4S2
SMILES

O=C(CC(SC1)=NC1=O)N/N=C(C2=CC=CC=C2)/C3=C(C4=CC=CC=C4)C(C(OCC)=O)=C(NC5=CC=CC=C5)S3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DNA Gyrase-IN-15 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DNA Gyrase-IN-15DNA/RNA SynthesisWI38Bacterial infectionAntimicrobialAntibiofilmESKAPEMWEnterococcus faecalis.Inhibitorinhibitorinhibit

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