2. Anti-infection
  3. Parasite
  4. DNDI-8219

DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 μM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 μM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety.

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DNDI-8219 Chemical Structure

DNDI-8219 Chemical Structure

CAS No. : 2222660-40-2

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Other Forms of DNDI-8219:

DNDI-8219 Related Antibodies

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Description

DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 μM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 μM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety.

IC50 & Target

Trypanosoma

 

In Vivo

DNDI-8219 (50 or 100 mg/kg; PO; once daily for five days) completely cures chronic infection, as well as markedly reduces?parasite burdens?in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (infected with T. cruzi; n=5)[1]
Dosage: 50 or 100 mg/kg
Administration: PO; once daily for five days
Result: Completely cured one of five mice in a chronic infection mouse model, as well as markedly reduced parasite burdens in two other mice.
Molecular Weight

345.23

Formula

C13H10F3N3O5
CAS No.
SMILES

FC(F)(F)OC1=CC=C(O[C@@H]2CN3C(OC2)=NC([N+]([O-])=O)=C3)C=C1
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DNDI-8219 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DNDI-82192222660-40-2DNDI8219DNDI 8219ParasiteTrypanosoma cruziTrypanocidalL6 cellsBALB/c miceOrally activeInhibitorinhibitorinhibit

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