2. Anti-infection
  3. Parasite
  4. DNDI-8219

DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 μM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 μM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety.

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DNDI-8219 Chemical Structure

DNDI-8219 Chemical Structure

CAS No. : 2222660-40-2

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Other Forms of DNDI-8219:

DNDI-8219 Related Antibodies

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Description

DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 μM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 μM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety.

IC50 & Target

Trypanosoma

 

Cellular Effect
Cell Line Type Value Description References
L6 IC50
> 100 μM
Compound: 58
Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay
Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay
[PMID: 33007723]
MRC5 IC50
> 64 μM
Compound: R-6
Cytotoxicity against human MRC5 cells after 72 hrs by resazurin dye based assay
Cytotoxicity against human MRC5 cells after 72 hrs by resazurin dye based assay
[PMID: 29461823]
In Vivo

DNDI-8219 (50 or 100 mg/kg; PO; once daily for five days) completely cures chronic infection, as well as markedly reduces?parasite burdens?in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (infected with T. cruzi; n=5)[1]
Dosage: 50 or 100 mg/kg
Administration: PO; once daily for five days
Result: Completely cured one of five mice in a chronic infection mouse model, as well as markedly reduced parasite burdens in two other mice.
Molecular Weight

345.23

Formula

C13H10F3N3O5
CAS No.
SMILES

FC(F)(F)OC1=CC=C(O[C@@H]2CN3C(OC2)=NC([N+]([O-])=O)=C3)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DNDI-8219 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DNDI-82192222660-40-2DNDI8219DNDI 8219ParasiteTrypanosoma cruziTrypanocidalL6 cellsBALB/c miceOrally activeInhibitorinhibitorinhibit

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