2. MAPK/ERK Pathway
  3. p38 MAPK
  4. Doramapimod (GMP)

Doramapimod GMP (BIRB 796 GMP) is an orally active inhibitor for p38 MAPK, with IC50s of 38, 65, 200 and 520 nM, for p38α, p38β, p38γ, p38δ. Doramapimod exhibits cytotoxicity and antitumor activity against multiple myeloma, synergizes with multidrug resistance protein 1 (ABCB1) and aurora kinase inhibitor VX680, promoting their antitumor efficacy against oral epidermoid carcinoma and cervical cancer. Doramapimod also exhibits anti-inflammatory activity.

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Doramapimod (GMP) Chemical Structure

Doramapimod (GMP) Chemical Structure

CAS No. : 285983-48-4

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Doramapimod (GMP) Related Antibodies

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Description

Doramapimod GMP (BIRB 796 GMP) is an orally active inhibitor for p38 MAPK, with IC50s of 38, 65, 200 and 520 nM, for p38α, p38β, p38γ, p38δ. Doramapimod exhibits cytotoxicity and antitumor activity against multiple myeloma, synergizes with multidrug resistance protein 1 (ABCB1) and aurora kinase inhibitor VX680, promoting their antitumor efficacy against oral epidermoid carcinoma and cervical cancer. Doramapimod also exhibits anti-inflammatory activity[1].

IC50 & Target

p38α

38 nM (IC50)

p38β

65 nM (IC50)

p38γ

200 nM (IC50)

p38δ

520 nM (IC50)

Molecular Weight

527.66

Formula

C31H37N5O3
CAS No.
SMILES

O=C(NC1=CC(C(C)(C)C)=NN1C2=CC=C(C)C=C2)NC3=C4C=CC=CC4=C(OCCN5CCOCC5)C=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Doramapimod (GMP) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Doramapimod (GMP)285983-48-4BIRB 796 (GMP)p38 MAPKorally activemultiple myelomaoral epidermoid carcinomacervical cancerInhibitorinhibitorinhibit

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