Doramapimod (Standard) (Synonyms: BIRB 796 (Standard))

Cat. No.: HY-10320R Purity: ≥98%: FAQs
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Doramapimod (Standard) is the analytical standard of Doramapimod. This product is intended for research and analytical applications. Doramapimod (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC50 for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM. Doramapimod has picomolar affinity for p38 kinase (Kd=0.1 nM). Doramapimod also inhibits B-Raf with an IC50 of 83 nM[1][2].

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Doramapimod (Standard) Chemical Structure

CAS No. : 285983-48-4

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Description	Doramapimod (Standard) is the analytical standard of Doramapimod . This product is intended for research and analytical applications. Doramapimod (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC50 for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM. Doramapimod has picomolar affinity for p38 kinase (Kd=0.1 nM). Doramapimod also inhibits B-Raf with an IC50 of 83 nM[1][2].
Molecular Weight	527.66
Formula	C₃₁H₃₇N₅O₃
CAS No.	285983-48-4
SMILES	O=C(NC1=CC(C(C)(C)C)=NN1C2=CC=C(C)C=C2)NC3=C4C=CC=CC4=C(OCCN5CCOCC5)C=C3
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Handling Instructions (2659 KB)

Doramapimod (Standard) Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Doramapimod (Standard)285983-48-4BIRB 796 (Standard)p38 MAPKRafAutophagyRaf kinasesInhibitorinhibitorinhibit

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Doramapimod (Standard) (Synonyms: BIRB 796 (Standard))

Product Information

Purity & Documentation

Customer Review

Doramapimod (Standard) Related Classifications

Molarity Calculator

Dilution Calculator