2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK Btk EGFR
  4. DPPY

DPPY (compound 6) is a potent PTK inhibitor with IC50 values of <10, <10, <10 nM for EGFR, BTK, JAK3, respectively. DPPY shows anti-proliferative activity against B-cell lymphoma cells. DPPY has the potential for the research of idiopathic pulmonary fibrosis (IPF).

For research use only. We do not sell to patients.

DPPY Chemical Structure

DPPY Chemical Structure

CAS No. : 2095883-62-6

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DPPY Related Antibodies

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JAK1 JAK2 JAK3 Tyk2 JAK

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Description

DPPY (compound 6) is a potent PTK inhibitor with IC50 values of <10, <10, <10 nM for EGFR, BTK, JAK3, respectively. DPPY shows anti-proliferative activity against B-cell lymphoma cells. DPPY has the potential for the research of idiopathic pulmonary fibrosis (IPF)[1].

IC50 & Target[1]

JAK3

<10 nM (IC50)

EGFR

<10 nM (IC50)

BTK

<10 nM (IC50)

Molecular Weight

507.97

Formula

C25H26ClN7O3
CAS No.
SMILES

C=CC(NC1=CC(NC2=NC(NC3=CC=C(C=C3)NC(CN4CCOCC4)=O)=NC=C2Cl)=CC=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DPPY Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DPPY2095883-62-6JAKBtkEGFRJanus kinaseBruton tyrosine kinaseEpidermal growth factor receptorErbB-1HER1idiopathic pulmonary fibrosisB-cell lymphoma cellsanti-proliferativeInhibitorinhibitorinhibit

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