DR4485 hydrochloride

Name: DR4485 hydrochloride
Brand: MedChemExpress
SKU: HY-103126
Rating: 4.5 (1 reviews)

Cat. No.: HY-103126: FAQs
Data Sheet Handling Instructions

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DR4485 (hydrochloride) is an orally active and selective 5-HT₇ antagonist (pK_i=8.14).

For research use only. We do not sell to patients.

DR4485 hydrochloride Chemical Structure

CAS No. : 402942-53-4

Size	Price	Stock	Quantity
5 mg	USD 515	Get quote 3 - 4 weeks 4 - 5 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	USD 824	Get quote 3 - 4 weeks 4 - 5 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 mg	USD 2472	Get quote 3 - 4 weeks 4 - 5 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

DR4485 (hydrochloride) is an orally active and selective 5-HT₇ antagonist (pK_i=8.14)^[1].

IC₅₀ & Target^[1]

5-HT₇ Receptor

8.14 (pKi)

In Vitro

DR4485 (MZ54 WT cells; 6 µM or 8 µM) hydrochloride induces autophagy as well as cell death that is diminished by KO of ATG5 and ATG7^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

491.88

Formula

C₂₆H₂₉Cl₃N₂O

CAS No.

402942-53-4

SMILES

O=C1NC2=C3C1(CCCCN4CC=C(C5=CC=C(Cl)C=C5)CC4)CCCC3=C(Cl)C=C2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kikuchi C, et al. New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability. Bioorg Med Chem Lett. 2003;13(1):61-64. [Content Brief]

[2]. Meyer N, et al. Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death [published online ahead of print, 2021 Jan 19]. Autophagy. 2021;1-20. [Content Brief]