DS-22-inf-021

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DS-22-inf-021 is a neuraminidase (NA) inhibitor. DS-22-inf-021 has antiviral activity against influenza viruses.

For research use only. We do not sell to patients.

DS-22-inf-021 Chemical Structure

CAS No. : 945170-74-1

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Description

DS-22-inf-021 is a neuraminidase (NA) inhibitor. DS-22-inf-021 has antiviral activity against influenza viruses^[1].

In Vitro

DS-22-inf-021 inhibits NA activity of IBV (B/Samara/32/2018 Yamagata lineage) and resistant IAV A/Vladivostok/2/2009 (H1N1 pdm09) carrying the H275Y mutation, with IC₅₀ values of 9.1 μM and 14.7 μM, respectively^[1].
DS-22-inf-021 (0.5-50 μM, 10 h) shows antiviral activity in MDCK cells were infected with IAV and IBV strains^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DS-22-inf-021 (20-100 mg/kg, i.p., twice daily for 5 days and monitored for 14 days. ) increased survival rate in mice infected with IAV and IBV^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	8-week-old female BALB/c mice, intranasally inoculated with 50 μL of five 50 % mouse lethal doses of IAV and IBV^[1].
Dosage:	20, 50 and 100 mg/kg
Administration:	After 2 h post-infection, i.p. injection
Result:	Reached 85 % protection at 100 mg/kg dose. For the B/Samara/32/2018 strain, it was observed that 100 % of mice treated with DS-22-inf-021 at 100 mg/kg.

Molecular Weight

337.42

Formula

C₂₀H₂₃N₃O₂

CAS No.

945170-74-1

SMILES

O=C(NC1=CC=C(NC(C2=CC=CC=C2)=O)C=C1)NC3CCCCC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Izmailyan R, et al. Discovery of new antiviral agents through artificial intelligence: In vitro and in vivo results. Antiviral Res. 2024 Feb;222:105818. [Content Brief]

DS-22-inf-021 Related Classifications

Infection

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DS-22-inf-021945170-74-1Influenza VirusMDCK cellIAVIBVinfluenza virusesInhibitorinhibitorinhibit

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